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古语云温故而知新，回顾以往的研究可以帮助研究人员了解新型冠状病毒，为攻克这一难题奠定基础。自然科研精心挑选了来自Nature Communications，Communications Biology以及Scientific Reports中的开放获取研究，内容涵盖冠状病毒家族的感染机制、药物发展以及疫苗研制等方向，希望为科研人员提供研究便利。
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冠状病毒蔓延的各种因素
2018
Nature Communications
Characterizing the dynamics underlying global spread of epidemics
2017
Global hotspots and correlates of emerging zoonotic diseases
2015
Scientific Reports
Inferring the hosts of coronavirus using dual statistical models based on nucleotide composition
2019
Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017
2016
The recent ancestry of Middle East respiratory syndrome coronavirus in Korea has been shaped by recombination
Using outbreak science to strengthen the use of models during epidemics
如何防止病毒蔓延的旧例
2020
Infection Prevention Measures for Surgical Procedures during a Middle East Respiratory Syndrome Outbreak in a Tertiary Care Hospital in South Korea
冠状病毒的药物发展
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody
Nanoparticulate vacuolar ATPase blocker exhibits potent host-targeted antiviral activity against feline coronavirus
X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design
Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein
Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design
Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis
Genetic drift of human coronavirus OC43 spike gene during adaptive evolution
冠状病毒的疫苗发展
Communications Biology
Evaluation of a recombination-resistant coronavirus as a broadly applicable, rapidly implementable vaccine platform
Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines
Evaluation of candidate vaccine approaches for MERS-CoV
冠状病毒的感染机制
Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission
Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection
SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection
Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
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