《自然-通讯》近期发表的一篇论文Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens指出，真菌化合物白霉素δ2具有成为抗生素的潜力。该研究介绍了一种在实验室高效合成白霉素δ2的新方法，并进一步测定了白霉素δ2对不同细菌的体外抗菌活性。
摘要：Development of effective antimicrobial agents continues to be a great challenge, particularly due to the increasing resistance of superbugs and frequent hospital breakouts. There is an urgent need for more potent and safer antibiotics with novel scaffolds. As historically many commercial drugs were derived from natural products, discovery of antimicrobial agents from complex natural product structures still holds a great promise. Herein, we report the total synthesis of natural albomycins δ1 (1a), δ2 (1b), and ε (1c), which validates the structures of these peptidylnucleoside compounds and allows for synthetic access to bioactive albomycin analogs. The efficient synthesis of albomycins enables extensive evaluations of these natural products against model bacteria and clinical pathogens. Albomycin δ2 has the potential to be developed into an antibacterial drug to treat Streptococcus pneumoniaeand Staphylococcus aureus infections.
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